There were more than 290 million chronic carriers worldwide as of July 2020 and approximately 30 million individuals become newly infected every year despite the availability of a prophylactic vaccine. In 2015, there were more than 90 million cases of Chronic HBV Infection in China alone, while the European Union, United States and Japan accounted for nearly 8 million cases. Complications from Chronic HBV Infection include cirrhosis, end-stage liver disease, and hepatocellular carcinoma, which collectively resulted in approximately 900,000 deaths in 2015, according to the World Health Organization. Chronic HBV Infection is the primary cause of liver cancer worldwide, and the mortality associated with HBV-related liver cancer continues to increase.