Preclinical, Publications Differentiation of HBV capsid assembly modulators based on stabilization of core protein oligomerization and residence time
Pevifoscorvir-sodium, Publications Capsid Assembly Modulator ALG-001075 Binds and Directly Targets HBeAg
Pevifoscorvir-sodium, Publications Sustained Reduction of HBV Antigen Levels During the 8-Week Follow-up Period in Treatment Naïve (TN) or Currently-Not-Treated (CNT) HBeAg-Positive Subjects with Chronic Hepatitis B Virus Infection After 96-Week 300 mg ALG-000184
ALG-055009, Publications A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG-055009, a novel thyroid hormone receptor beta (THR-β) agonist for metabolic dysfunction-associated steatohepatitis (MASH), in healthy participants
Pevifoscorvir-sodium, Publications The CAM-E ALG-001075 potently reduces HBV cccDNA in preclinical experiments
Preclinical, Publications Antisense oligonucleotide-based strategy to target hepatitis delta virus infections
Preclinical, Publications Differential impact of CAM-E and CAM-A on hepatitis B core protein phosphorylation states in vitro
Preclinical, Publications PML nuclear bodies store aggregated HBc and reduce CAM-induced apoptosis in HBc-expressing cells