Though Woodchuck hepatitis virus (WHBV), a related virus, was discovered in Woodchucks in 1978, it wasn’t until ~2000 that it began to be utilized in the development of antiviral therapies. This marked the beginning of the renaissance in HBV drug development. Before the availability of the Woodchuck model, it was not possible to show the effects of NAs in nonclinical models or validate in vitro HBV data.